Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 3
Articles | Volume 11, issue 3
https://doi.org/10.5194/jbji-11-373-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-373-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 3
Review
 | 
29 Jun 2026
Review |  | 29 Jun 2026

Integrating molecular and conventional diagnostics in native vertebral osteomyelitis: a narrative review

Farzad Pourghazi, Omar Mahmoud, Francesco Petri, Said El Zein, Gina A. Suh, Takahiro Matsuo, Andrea Gori, Audrey N. Schuetz, and Elie F. Berbari

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Short summary
Native vertebral osteomyelitis, a spinal bone infection, is difficult to diagnose, and delays can worsen outcomes. This review examines how traditional laboratory tests and newer genetic techniques can be integrated to improve identification of the responsible microorganism. We show that combining these approaches within the diagnostic pathway may increase accuracy and support earlier diagnosis, enabling more timely and informed treatment decisions.
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