Articles | Volume 11, issue 3
https://doi.org/10.5194/jbji-11-355-2026
https://doi.org/10.5194/jbji-11-355-2026
Original full-length article
 | 
19 Jun 2026
Original full-length article |  | 19 Jun 2026

Gram-negative prosthetic joint infections: a retrospective multicentre European study of incidence, risk factors, and treatment outcomes

Ernest Famada Arboix, Arnaud Fischbacher, Matteo Carlo Maria Ferrari, Olivier Borens, and Daniel Pérez-Prieto

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Cited articles

Anon: American Academy of Orthopaedic Surgeons EvidenceBased Clinical Practice Guideline for Diagnosis and Prevention of Periprosthetic Joint Infections, https://www.aaos.org/pjicpg (last access: 11 March 2019), 2019. 
Bassetti, M., Righi, E., Pecori, D., and Tillotson, G.: Delafloxacin: An Improved Fluoroquinolone Developed through Advanced Molecular Engineering, Future Microbiol., 13, 1081–1094, https://doi.org/10.2217/fmb-2018-0067, 2018. 
Casenaz, A., Piroth, L., Labattut, L., Sixt, T., Magallon, A., Guilloteau, A., Neuwirth, C., and Amoureux, L.: Epidemiology and antibiotic resistance of prosthetic joint infections according to time of occurrence, a 10-year study, J. Infect., 85, 492–498, https://doi.org/10.1016/j.jinf.2022.07.009, 2022. 
Chang, Y., Li, Y., Fan, T., Jiang, K., Lv, J., and Huang, J.: Pathogenic bacteria characteristics and drug resistance in acute, delayed, and chronic periprosthetic joint infection: A retrospective analysis of 202 patients, Int. Wound J., 20, 3315–3323, https://doi.org/10.1111/iwj.14212, 2023. 
Fantoni, M., Borrè, S., Rostagno, R., Riccio, G., Carrega, G., Giovannenze, F., and Taccari, F.: Epidemiological and clinical features of prosthetic joint infections caused by gram-negative bacteria, Eur. Rev. Med. Pharmacol. Sci., 23, 187–194, https://doi.org/10.26355/eurrev_201904_17490, 2019. 
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Short summary
Gram-negative prosthetic joint infections are challenging. Robust European multicentre data remain limited. This study provides contemporary epidemiological and microbiological data from three tertiary centers across three European countries. We identify patient risk profiles and pathogen-related differences in treatment success. These findings offer novel, practical evidence to guide individualized management of gram-negative prosthetic joint infection (PJI).
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