Articles | Volume 11, issue 3
https://doi.org/10.5194/jbji-11-331-2026
https://doi.org/10.5194/jbji-11-331-2026
Review
 | 
05 Jun 2026
Review |  | 05 Jun 2026

Primary hip or knee arthroplasty in the setting of chronic suppressive antibiotics for prior periprosthetic joint infection: a scoping review

Vincent K. Melemai, Ryan J. Blake, Christian Barill, Adam E. Klein, Matthew J. Dietz, and Allison M. Lastinger

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Cited articles

Aboltins, C., Lemoh, C., Suleiman, M., Soriano, A., Davis, J., and Manning, L.: Outcomes after suppressive antimicrobial therapy for prosthetic joint infection: a prospective cohort study, Antimicrob. Agents Chemother., 69, 0178424, https://doi.org/10.1128/aac.01784-24, 2025. 
Bedair, H., Goyal, N., Dietz, M. J., Urish, K., Hansen, V., Manrique, J., Hamilton, W., and Deirmengian, G.: A History of Treated Periprosthetic Joint Infection Increases the Risk of Subsequent Different Site Infection, Clin. Orthop. Relat. Res., 473, 2300–2304, https://doi.org/10.1007/s11999-015-4174-4, 2015. 
Chalmers, B. P., Weston, J. T., Osmon, D. R., Hanssen, A. D., Berry, D. J., and Abdel, M. P.: Prior hip or knee prosthetic joint infection in another joint increases risk three-fold of prosthetic joint infection after primary total knee arthroplasty: a matched control study, Bone Joint J., 101, 91–97, https://doi.org/10.1302/0301-620X.101B7.BJJ-2018-1189.R1, 2019. 
Chalmers, B. P., Berbari, E. F., Osmon, D. R., Hanssen, A. D., Berry, D. J., and Abdel, M. P.: Elevated Infection and Complication Rates in Patients Undergoing a Primary THA With a History of a PJI in a Prior Hip or Knee Arthroplasty: A Matched Cohort Study, J. Arthroplasty, 35, 1928–1932, https://doi.org/10.1016/j.arth.2020.02.018, 2020. 
Dobson, P. F. and Reed, M. R.: Prevention of infection in primary THA and TKA, EFORT Open Rev., 5, 604–613, https://doi.org/10.1302/2058-5241.5.200004, 2020. 
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Short summary
Total joint arthroplasty is increasingly common in the US, with an expected rise in periprosthetic joint infection (PJI). Limited evidence exists of PJI risk in new primary arthroplasty in patients on chronic suppression for prior PJI. Due to a lack of evidence examining this population, shared decision-making must be informed by medical comorbidities and patient-related risk factors, infectious history, and the current evidence of PJI treatment and infection control measures.
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