Articles | Volume 11, issue 3
https://doi.org/10.5194/jbji-11-277-2026
https://doi.org/10.5194/jbji-11-277-2026
Review
 | 
18 May 2026
Review |  | 18 May 2026

The use of debridement, antibiotic pearls, and implant retention (DAPRI) in the management of acute periprosthetic joint infections: a systematic review

Doriana Di Costa, Giacomo Capece, Donato Coppola, Elena Matteini, Pierluigi Del Vecchio, Francesco Taccari, Giuseppe Maccagnano, Carlo Torti, Giulio Maccauro, and Raffaele Vitiello

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Cited articles

Abbaszadeh, A., Yilmaz, M. K., Izadi, N., Hoveidaei, A. H., Taheriazam, A., Abedi, A. A., and Parvizi, J.: Efficacy of Debridement, Antibiotics, and Implant Retention in Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis, J. Arthroplasty, 41, 19–38, https://doi.org/10.1016/j.arth.2025.05.121, 2026. 
Aggarwal, V. K., Rasouli, M. R., and Parvizi, J.: Periprosthetic Joint Infection: Current Concept, Indian J. Orthop., 47, 10–17, https://doi.org/10.4103/0019-5413.106884, 2013. 
Andriollo, L., Sangaletti, R., Velluto, C., Perticarini, L., Benazzo, F., and Rossi, S. M. P.: Impact of a Novel Antiseptic Lavage Solution on Acute Periprosthetic Joint Infection in Hip and Knee Arthroplasty, J. Clin. Med., 13, 3092, https://doi.org/10.3390/jcm13113092, 2024. 
Ayoade, F., Li, D., Mabrouk, A., and Todd, J. R.: Periprosthetic Joint Infection, in: StatPearls, StatPearls Publishing, Treasure Island (FL), PMID: 28846340, 2025. 
Balato, G., Ascione, T., De Matteo, V., Lenzi, M., Amato, M., De Giovanni, R., Festa, E., and Mariconda, M.: Debridement and Implant Retention in Acute Hematogenous Periprosthetic Joint Infection after Knee Arthroplasty: A Systematic Review, Orthop. Rev., 14, https://doi.org/10.52965/001c.33670, 2022. 
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Short summary
This systematic review evaluates debridement, antibiotic pearls and implant retention (DAPR) as a treatment option for acute periprosthetic joint infection. Analysis of available clinical studies shows encouraging infection control rates with few complications, suggesting that this approach may help to preserve implants in selected patients. However, current evidence is limited, and larger well-designed studies are needed to confirm its effectiveness and clarify its role in clinical practice.
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