Articles | Volume 11, issue 3
https://doi.org/10.5194/jbji-11-267-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-267-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Adverse events and tolerability of long-term suppressive antibiotic therapy for periprosthetic joint infection: a prospective cohort study
Pia Reinecke
Charité – Universitätsmedizin Berlin, Centre for Musculoskeletal Surgery, corporate member of Freie Universität Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Berlin, Germany
Svetlana Karbysheva
Charité – Universitätsmedizin Berlin, Centre for Musculoskeletal Surgery, corporate member of Freie Universität Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Berlin, Germany
Stavros Goumenos
Charité – Universitätsmedizin Berlin, Centre for Musculoskeletal Surgery, corporate member of Freie Universität Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Berlin, Germany
Anna Conen
Clinic for Infectious Diseases and Infection Prevention, Kantonsspital Aarau, Aarau, Switzerland
Olga Pidgaiska
Charité – Universitätsmedizin Berlin, Centre for Musculoskeletal Surgery, corporate member of Freie Universität Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Berlin, Germany
Carsten Perka
Charité – Universitätsmedizin Berlin, Centre for Musculoskeletal Surgery, corporate member of Freie Universität Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Berlin, Germany
Andrej Trampuz
School of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia
Royal Brisbane and Women's Hospital, Herston, Queensland, Australia
Thilo Khakzad
Charité – Universitätsmedizin Berlin, Centre for Musculoskeletal Surgery, corporate member of Freie Universität Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Berlin, Germany
Sebastian Meller
CORRESPONDING AUTHOR
Charité – Universitätsmedizin Berlin, Centre for Musculoskeletal Surgery, corporate member of Freie Universität Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Domenico De Mauro, Chiara Comisi, Valeria Maccauro, Giovanni Balato, Sebastian Meller, Martina Di Martino, Fabiana Arduini, Giulio Maccauro, and Raffaele Vitiello
J. Bone Joint Infect., 11, 139–147, https://doi.org/10.5194/jbji-11-139-2026, https://doi.org/10.5194/jbji-11-139-2026, 2026
Short summary
Short summary
This retrospective study analyzed 682 patients who underwent primary total hip or knee arthroplasty to evaluate the impact of malnutrition on post-operative outcomes. Malnutrition, as defined by the Nutritional Risk Screening 2002 (NRS-2002) and controlling nutritional status (CONUT) scores, was significantly associated with higher rates of post-operative infection and poorer quality-of-life scores. Early nutritional assessment may improve post-operative recovery and reduce complication rates.
Andreas G. Tsantes, Dimitrios V. Papadopoulos, Stavros Goumenos, Eleni Petrou, Ioannis G. Trikoupis, Anastasios Roustemis, Alexandra Mpakosi, Petros Ioannou, Christos Koutserimpas, Panayiotis Gavriil, Daniele Piovani, Stefanos Bonovas, Panayiotis J. Papagelopoulos, Athanasios Tsakris, and Argirios E. Tsantes
J. Bone Joint Infect., 10, 337–345, https://doi.org/10.5194/jbji-10-337-2025, https://doi.org/10.5194/jbji-10-337-2025, 2025
Short summary
Short summary
Our results indicate that certain parameters such as diabetes, low albumin levels, and prolonged duration of surgery are associated with a higher risk of infection in patients undergoing musculoskeletal tumor resection and megaprosthetic reconstruction. Strategies targeted towards glycemic control and nutritional status optimization are of great significance, while parameters that can affect the operating time can also have a positive impact on periprosthetic joint infection prevention.
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Short summary
This study examined how people with difficult joint infections manage long-term antibiotic treatment when the infection cannot be fully removed. We followed patients to record side effects and overall well-being. Many had stomach or skin problems, but most continued treatment. The results show that attentive follow-up and personalised care keep this therapy manageable and may guide better support in practice.
This study examined how people with difficult joint infections manage long-term antibiotic...