Articles | Volume 11, issue 3
https://doi.org/10.5194/jbji-11-267-2026
https://doi.org/10.5194/jbji-11-267-2026
Original full-length article
 | 
12 May 2026
Original full-length article |  | 12 May 2026

Adverse events and tolerability of long-term suppressive antibiotic therapy for periprosthetic joint infection: a prospective cohort study

Pia Reinecke, Svetlana Karbysheva, Stavros Goumenos, Anna Conen, Olga Pidgaiska, Carsten Perka, Andrej Trampuz, Thilo Khakzad, and Sebastian Meller

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Cited articles

Bindel, L. J. and Seifert, R.: Development of bacterial resistance in Germany from 2008 to 2022 – major culprit pathogens, antibacterial drugs, and prescribing practices, Naunyn. Schmiedebergs Arch. Pharmacol., 398, 4219–4236, https://doi.org/10.1007/s00210-024-03533-6, 2025. 
Burr, R. G., Eikani, C. K., Adams, W. H., Hopkinson, W. J., and Brown, N. M.: Predictors of Success With Chronic Antibiotic Suppression for Prosthetic Joint Infections, J. Arthroplasty, 37, S983–s988, https://doi.org/10.1016/j.arth.2022.02.003, 2022. 
Edwards, I. R. and Aronson, J. K.: Adverse drug reactions: definitions, diagnosis, and management, Lancet, 356, 1255–1259, https://doi.org/10.1016/s0140-6736(00)02799-9, 2000. 
Escudero-Sánchez, R., Ponce-Alonso, M., Barragán-Prada, H., Morosini, M. I., Cantón, R., Cobo, J., and Del Campo, R.: Long-Term Impact of Suppressive Antibiotic Therapy on Intestinal Microbiota, Genes, 12, https://doi.org/10.3390/genes12010041, 2020b. 
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Short summary
This study examined how people with difficult joint infections manage long-term antibiotic treatment when the infection cannot be fully removed. We followed patients to record side effects and overall well-being. Many had stomach or skin problems, but most continued treatment. The results show that attentive follow-up and personalised care keep this therapy manageable and may guide better support in practice.
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