Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 10, issue 6
Articles | Volume 10, issue 6
https://doi.org/10.5194/jbji-10-609-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-609-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 10, issue 6
Original full-length article
 | 
19 Dec 2025
Original full-length article |  | 19 Dec 2025

Renal safety of intraoperative local vancomycin powder application in orthopedic surgery: a retrospective analysis

Juliane Beschauner, Maria Felsberg, Alexander Zeh, Karl-Stefan Delank, Natalia Gutteck, and Felix Werneburg

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Latest update: 09 Oct 2026
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Short summary
We studied whether placing vancomycin powder directly into the wound during orthopedic surgery harms the kidneys. In 50 patients, kidney function before and after surgery stayed essentially stable, even with higher doses. Our findings suggest that this local antibiotic strategy is unlikely to cause short-term kidney damage.
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