Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 10, issue 6
Articles | Volume 10, issue 6
https://doi.org/10.5194/jbji-10-511-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-511-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 10, issue 6
Original full-length article
 | 
02 Dec 2025
Original full-length article |  | 02 Dec 2025

Assessing the efficacy of systemic antibiotics for biofilm-associated infection in an ovine model of simulated fracture-related infection

Robert Falconer, David Rothberg, Walker Kay, Connor Hunt, Richard Tyler Epperson, Brooke Kawaguchi, Nicholas Ashton, and Dustin Williams

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Short summary
This study evaluated the effectiveness of systemic antibiotic therapy against S. aureus and P. aeruginosa biofilm-associated infections in a large animal (ovine) model of fracture-related infection (FRI). Systemic therapy reduced some bacterial load, but most samples did not significantly differ from positive controls. Histological findings corroborated persistent infection. These results validate the model and underscore the limitations of systemic therapy in effectively managing FRI.
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