Articles | Volume 10, issue 6
https://doi.org/10.5194/jbji-10-447-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-447-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Implementation of a novel process for post-discharge microbiology results review for musculoskeletal infections in a large-volume academic healthcare system
Margaret Pertzborn
CORRESPONDING AUTHOR
Department of Pharmacy, Mayo Clinic Health System – Northwest Wisconsin Region, Eau Claire, Wisconsin, 54702, United States
Amy L. Van Abel
Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, 55905, United States
Trudi Lane
Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, 55905, United States
Kristin Cole
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, 55905, United States
Douglas Osmon
Division of Public Health, Infectious Diseases, Occupational Medicine, Mayo Clinic, Rochester, Minnesota, 55905, United States
Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, 55905, United States
Diana J. Schreier
Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, 55905, United States
Hilary Teaford
Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, 55905, United States
Courtney M. Willis
Department of Pharmacy, Mayo Clinic, Jacksonville, Florida, 32224, United States
Anna Woods
Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, 55905, United States
Raymund R. Razonable
Division of Public Health, Infectious Diseases, Occupational Medicine, Mayo Clinic, Rochester, Minnesota, 55905, United States
Abinash Virk
Division of Public Health, Infectious Diseases, Occupational Medicine, Mayo Clinic, Rochester, Minnesota, 55905, United States
Christina G. Rivera
Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, 55905, United States
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Ryan B. Khodadadi, Jack W. McHugh, Supavit Chesdachai, Nancy L. Wengenack, Wendelyn Bosch, Maria Teresa Seville, Douglas R. Osmon, Elena Beam, and Zachary A. Yetmar
J. Bone Joint Infect., 9, 207–212, https://doi.org/10.5194/jbji-9-207-2024, https://doi.org/10.5194/jbji-9-207-2024, 2024
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In a multicenter retrospective study of musculoskeletal Nocardia infections (2011–2022), nine cases were identified. Disseminated disease occurred in 33 %, all in solid organ transplant recipients. Surgical intervention was common (89 %), with varied treatment duration (21–467 d). The 1-year mortality was 22%; all fatal cases involved disseminated disease. Localized infection generally had favorable outcomes compared to disseminated disease and requires a collaborative approach for management.
Said El Zein, Elie F. Berbari, Allison M. LeMahieu, Anil Jagtiani, Parham Sendi, Abinash Virk, Mark E. Morrey, and Aaron J. Tande
J. Bone Joint Infect., 9, 107–115, https://doi.org/10.5194/jbji-9-107-2024, https://doi.org/10.5194/jbji-9-107-2024, 2024
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Our study investigated olecranon septic bursitis treatment, focusing on postsurgical antibiotic use. Analyzing 22 years of Mayo Clinic data, we found that smoking and not administering antibiotics following surgery led to poorer outcomes. A 3-week antibiotic course following surgery was most effective. Our findings suggest that a subset of patients may benefit from longer courses of antibiotics; however, further research is needed to confirm these findings.
Christin A. Tiegs-Heiden, Tanner C. Anderson, Mark S. Collins, Matthew P. Johnson, Douglas R. Osmon, and Doris E. Wenger
J. Bone Joint Infect., 8, 99–107, https://doi.org/10.5194/jbji-8-99-2023, https://doi.org/10.5194/jbji-8-99-2023, 2023
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Magnetic resonance imaging (MRI) is an imaging test that is often used in patients with a suspected bone infection in their foot. MRI findings may impact how these patients are treated; thus, it is important to understand the significance of various MRI findings. This study compared different patterns of MRI findings in these patients to their clinical outcomes. Patients with classic features of bone infection on MRI had the worst outcomes, whereas patients without them sometimes healed.
Holly Duck, Suzanne Tanner, Debra Zillmer, Douglas Osmon, and Kevin Perry
J. Bone Joint Infect., 6, 393–403, https://doi.org/10.5194/jbji-6-393-2021, https://doi.org/10.5194/jbji-6-393-2021, 2021
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This paper describes an ultrasound guided technique for aspiration of hip arthroplasties that has not been published. We believe this technique is important because it yields useful fluid 99 % of the time with low contamination rate (2 %). Ultrasound, although common in Europe, is gaining popularity in the United States. Besides teaching a useful technique, this paper also discusses findings of lavage-obtained samples which are rarely discussed in other aspiration papers.
Talha Riaz, Mark Collins, Mark Enzler, Marco Rizzo, Audrey N. Schuetz, Julia S. Lehman, Douglas Osmon, and Irene G. Sia
J. Bone Joint Infect., 6, 355–361, https://doi.org/10.5194/jbji-6-355-2021, https://doi.org/10.5194/jbji-6-355-2021, 2021
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Tenosynovitis due to Histoplasma capsulatum in an immunocompromised host warrants special attention. Following surgical debridement, the patient initially improved on antifungal therapy, but as immunosuppression was decreased, she presented with a flare, requiring further debridement. With negative fungal cultures and declining antigenemia, it was felt that her interim worsening was as a consequence of immune reconstitution inflammatory syndrome (IRIS).
Don Bambino Geno Tai, Nathan J. Brinkman, Omar Abu Saleh, Douglas R. Osmon, Matthew P. Abdel, and Christina G. Rivera
J. Bone Joint Infect., 6, 147–150, https://doi.org/10.5194/jbji-6-147-2021, https://doi.org/10.5194/jbji-6-147-2021, 2021
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Antibiotics are frequently used in bone cement during joint replacements or treatment of bone and joint infections. Amikacin is rarely used in bone cement, particularly the liquid formulation. We describe a series of patients in which liquid amikacin was incorporated into bone cement. We did not observe the occurrence of adverse drug reactions definitively attributed to its use. All patients had favorable outcomes.
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Short summary
Patients with bone and joint infections are often sent home before all test results are final. We created a new team-based process to review these results after discharge and take action if needed. In over one-third of cases, changes to treatment were made, some of which prevented serious harm. This approach improves patient safety and shows how teamwork and follow-up after hospital stays can make a meaningful difference in care.
Patients with bone and joint infections are often sent home before all test results are final....