Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 10, issue 4
Articles | Volume 10, issue 4
https://doi.org/10.5194/jbji-10-285-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-285-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 10, issue 4
Original full-length article
 | 
12 Aug 2025
Original full-length article |  | 12 Aug 2025

Inadequate empirical antibiotics following debridement for orthopedic infections do not increase therapy failures

Steven Mark Maurer, Marc Simon Maurer, Marc Schmid, Stefani Dossi, Lucienne Gautier, Aileen Elizabeth Boyd, Mazda Farshad, and Ilker Uçkay

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Short summary

Empirical antibiotics should target likely pathogens if stewardship is followed, yet broader coverage is often used in orthopedic infections due to fear of failure. This retrospective case-control study examined surgically managed orthopedic infections, comparing accurate and inaccurate empirical antibiotic choices. Delays in switching to targeted antibiotics did not impact outcomes. Broad-spectrum regimens offered no advantage, supporting narrower choices for mild to moderate infections.

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