Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 10, issue 4
Articles | Volume 10, issue 4
https://doi.org/10.5194/jbji-10-217-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-217-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 10, issue 4
Original full-length article
 | 
14 Jul 2025
Original full-length article |  | 14 Jul 2025

Risk factors for treatment failure in late acute periprosthetic joint infection in patients with rheumatoid arthritis treated with surgical debridement – a case-control study

Hendrika M. Schenk, Marine Sebillotte, Jose Lomas, Adrian Taylor, Eva Benavent, Oscar Murillo, Marta Fernandez-Sampedro, Kaisa Huotari, Craig Aboltins, Rihard Trebse, Alex Soriano, Marjan Wouthuyzen-Bakker, and on behalf of the ESCMID Study Group on Implant Associated Infections (ESGIAI)

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Cited articles

Austin, P. C.: Statistical Criteria for Selecting the Optimal Number of Untreated Subjects Matched to Each Treated Subject When Using Many-to-One Matching on the Propensity Score, Am. J. Epidemiol., 172, 1092–1097, https://doi.org/10.1093/aje/kwq224, 2010. 
Bari, S. F., Khan, A., and Lawson, T.: C reactive protein may not be reliable as a marker of severe bacterial infection in patients receiving tocilizumab, Case Rep., 2013, bcr2013010423, https://doi.org/10.1136/bcr-2013-010423, 2013. 
Barrett, L. and Atkins, B.: The clinical presentation of prosthetic joint infection, J. Antimicrob. Chemother., 69, i25–i27, https://doi.org/10.1093/jac/dku250, 2014. 
Berbari, E. F., Osmon, D. R., Duffy, M. C. T., Harmssen, R. N. W., Mandrekar, J. N., Hanssen, A. D., and Steckelberg, J. M.: Outcome of Prosthetic Joint Infection in Patients with Rheumatoid Arthritis: The Impact of Medical and Surgical Therapy in 200 Episodes, Clin. Infect. Dis., 42, 216–223, https://doi.org/10.1086/498507, 2006. 
Cipriano, C. A., Brown, N. M., Michael, A. M., Moric, M., Sporer, S. M., and Della Valle, C. J.: Serum and Synovial Fluid Analysis for Diagnosing Chronic Periprosthetic Infection in Patients with Inflammatory Arthritis, J. Bone Joint Surg., 94, 594–600, https://doi.org/10.2106/JBJS.J.01318, 2012. 
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Short summary
Patients with rheumatoid arthritis have a high treatment failure rate when faced with a late acute periprosthetic joint infection. Because of the rarity of the condition, we performed a multicenter case-control study. We identified predictors of treatment failure to ultimately improve the treatment outcome. Exchange of modular components seems important in this patient group, likely due to a higher rate of positive blood cultures compared to control patients.
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