Our goal was to evaluate the results of two-stage revision of hip periprosthetic joint infection (PJI) over a 20-year period. Our arthroplasty unit is the largest in Ireland. We obtained data for a large number of cases (158 hips) with mid-term to long-term follow-up. Our analysis has found an infection-free survival rate of 84.2 % at 10 years, which was comparable with the best available outcomes. Most of the previously published risk factors were not predictive of failure in our study.

Antibiotics are often used to reduce the rate of recurrent periprosthetic joint infection (PJI) in patients with prior PJI. This study found that patients treated with such prophylactic antibiotics had an increased rate of infection with antibiotic-resistant organisms in any recurrent PJIs that occurred.

To improve the existing knowledge and treatment of bone and joint infections, it is essential to unite medical disciplines and bridge the gap between basic and clinical sciences. In 2018, the Centrum fOr translational Medicine on Bone and joint INfEctions (COMBINE) was created to facilitate collaboration among Danish scientists and researchers dedicated to bone and joint infection research. This paper aims to share the COMBINE approach and values.

We present a case of post-traumatic fracture-related infection with the unusual bacteria Metamycoplasma hominis, usually only seen in people with impaired immune systems. Treatment required multiple surgeries, combined with 10 weeks of treatment with the antibiotics doxycycline and clindamycin. There are no guidelines on treatment, but we recommend a multi-disciplinary team approach, with prolonged antibiotic treatment personalised to the patient based on sensitivities of the organism.

Implant-related osteomyelitis is common in orthopedics. Absorbable antibiotic-loaded calcium sulfate (ACS) is an alternative to nonabsorbable antibiotic depot options for osteomyelitis and fracture-related infections. This study aims to evaluate intramedullary canal filling and coating characteristics of ACS around tibial nails using a tibia SAWBONES model. This research was done to better understand the potential utility of ACS in situations requiring fixation in the setting of local infection.