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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Volume 4, issue 1
J. Bone Joint Infect., 4, 50–55, 2019
https://doi.org/10.7150/jbji.30615
© Author(s) 2019. This work is distributed under
the Creative Commons Attribution 4.0 License.
J. Bone Joint Infect., 4, 50–55, 2019
https://doi.org/10.7150/jbji.30615
© Author(s) 2019. This work is distributed under
the Creative Commons Attribution 4.0 License.

Case report 29 Jan 2019

Case report | 29 Jan 2019

Metagenomic next-generation sequencing contribution in identifying prosthetic joint infection due to Parvimonas micra: a case report

Zida Huang1, Chongjing Zhang1, Wenbo Li1, Xinyu Fang1, Qijin Wang1, Li Xing3, Yingzhen Li3, Xifang Nie3, Bin Yang2, and Wenming Zhang1 Zida Huang et al.
  • 1Department of Orthopedic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, China
  • 3BGI Genomics, BGI-Shenzhen, Shenzhen 518083, China
  • 2Department of Laboratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, China

Keywords: Prosthetic joint infection, Parvimonas micra, Metagenomic next-generation sequencing

Abstract. Identifying fastidious pathogens in patients with prosthetic joint infection (PJI) by culture is challenging. Metagenomic next-generation sequencing (mNGS) is a novel culture-independent approach that is associated with a higher likelihood for identifying pathogens. We present a case where mNGS was implemented to identify Parvimonas micra, a rarely reported and difficult-to-culture PJI pathogen.

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