Journal cover Journal topic
Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
Journal topic

Journal metrics

h5-index value: 15
h5-index15
Volume 3, issue 2
J. Bone Joint Infect., 3, 50–67, 2018
https://doi.org/10.7150/jbji.23423
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.
J. Bone Joint Infect., 3, 50–67, 2018
https://doi.org/10.7150/jbji.23423
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.

Review 12 Apr 2018

Review | 12 Apr 2018

Current therapies in treatment and prevention of fracture wound biofilms: why a multifaceted approach is essential for resolving persistent infections

Krystle A. Blanchette and Joseph C. Wenke Krystle A. Blanchette and Joseph C. Wenke
  • US Army Institute of Surgical Research, Ft Sam Houston, TX

Keywords: Biofilm, wound care, chronic infection, persistent infection, antimicrobial treatment

Abstract. Traumatic orthopedic injuries, particularly extremity wounds, are a significant cause of morbidity. Despite prophylactic antibiotic treatment and surgical intervention, persistent infectious complications can and do occur. Persistent bacterial infections are often caused by biofilms, communities of antibiotic tolerant bacteria encased within a matrix. The structural and metabolic differences in this mode of growth make treatment difficult. Herein, we describe both established and novel, experimental treatments targeted at various stages of wound healing that are specifically aimed at reducing and eliminating biofilm bacteria. Importantly, the highly tolerant nature of these bacterial communities suggests that most singular approaches could be circumvented and a multifaceted, combinatorial approach will be the most effective strategy for treating these complicated infections.

Publications Copernicus
Download
Citation