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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Volume 3, issue 5
J. Bone Joint Infect., 3, 255–257, 2018
https://doi.org/10.7150/jbji.30029
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.
J. Bone Joint Infect., 3, 255–257, 2018
https://doi.org/10.7150/jbji.30029
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.

Brief report 24 Nov 2018

Brief report | 24 Nov 2018

Rifampin-Resistant Cutibacterium (formerly Propionibacterium) namnetense Superinfection after Staphylococcus aureus Bone Infection Treatment

Stéphane Corvec1,2,3, Aurélie Guillouzouic1, Guillaume Ghislain Aubin1, Sophie Touchais3,4, Olivier Grossi3,5, François Gouin3,4, and Pascale Bémer1,3 Stéphane Corvec et al.
  • 1Service de Bactériologie-Hygiène hospitalière, CHU de Nantes, Nantes, France
  • 2CRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France
  • 3Nantes study group member of CRIOGO (Centre de Référence des Infections Ostéo-articulaires du Grand Ouest), Nantes, France
  • 4Clinique chirurgicale orthopédique et traumatique, CHU de Nantes, Nantes, France.
  • 5Service de Maladies infectieuses, CHU de Nantes, Nantes, France - Département de Médecine Interne -Infectiologie, Nouvelles Cliniques Nantaises, Nantes, France

Keywords: bone infection, rifampin, Cutibacterium namnetense, Staphylococcus aureus, resistance

Abstract. After rifampin and levofloxacin treatment for a Staphylococcus aureus bone infection, a pyogenic granuloma due to a newly described Cutibacterium species, C. namnetense developed on the tibia former external fixator. This rifampin resistant bacterium, selected during treatment, harbored a mutation in the rpoB gene. This case illustrates the possible in vivo selection of resistant mutant most likely due to the bacterial burden and therefore the importance of adequate bone infection treatment.

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