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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Volume 2, issue 1
J. Bone Joint Infect., 2, 23–28, 2017
https://doi.org/10.7150/jbji.16649
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 4.0 License.
J. Bone Joint Infect., 2, 23–28, 2017
https://doi.org/10.7150/jbji.16649
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 4.0 License.

Review 01 Jan 2017

Review | 01 Jan 2017

Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery

Andrew N. Fleischman and Matthew S. Austin Andrew N. Fleischman and Matthew S. Austin
  • Rothman Institute, Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, United States.

Keywords: Surgical site infection, orthopaedic surgery

Abstract. Surgical site infection (SSI) is one of the most common complications after orthopaedic surgery, leading to significant morbidity and its associated costs. Surgical guidelines strongly recommend the use of systemic antibiotic prophylaxis to reduce the risk for developing SSI. Locally administered powdered antibiotics have the potential to provide remarkably high intra-wound concentrations without risk for systemic toxicity. However, a paucity of high quality evidence in the orthopaedic literature has prevented widespread adoption of this technique. The majority of clinical studies on local intra-wound antibiotics have evaluated the use of topical powdered vancomycin in spinal surgery, though only a single prospective study currently exists. This review will discuss all the available evidence describing the effectiveness, pharmacokinetics, and potential adverse effects with the use of topical powdered antibiotics in orthopedic surgery.

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