Journal cover Journal topic
Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
Journal topic

Journal metrics

h5-index value: 15
h5-index15
Volume 1, issue 1
J. Bone Joint Infect., 1, 50–53, 2016
https://doi.org/10.7150/jbji.16353
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 4.0 License.
J. Bone Joint Infect., 1, 50–53, 2016
https://doi.org/10.7150/jbji.16353
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 4.0 License.

Brief report 01 Aug 2016

Brief report | 01 Aug 2016

Leishmania Infection of a Knee Megaprosthesis

John Papanastasiou2, Andreas F. Mavrogenis1, Dimitris Flevas1, Panayiotis D. Megaloikonomos1, Emmanouil Kolimpianakis2, Ioanna Iakovidou3, Panayiotis J. Papagelopoulos1, and Nikolaos Demertzis2 John Papanastasiou et al.
  • 2The Department of Orthopaedics, Ag. Anargyroi Hospital, Athens, Greece;
  • 1The First Department of Orthopaedics, Athens University Medical School, ATTIKON University Hospital, Athens, Greece;
  • 3The Department of Pathology, Metaxa Hospital, Athens, Greece.

Keywords: Leishmaniasis, Knee megaprosthesis.

Abstract. This article presents a 19-year old patient with a distal femoral osteosarcoma treated with limb salvage and distal femoral megaprosthetic reconstruction complicated postoperatively by bone leishmaniasis. Bone biopsy was done; bone tissue was sent for cultures and histology. Cultures were negative. Histological sections showed Leishman - Donovan bodies within histiocytes confirming the diagnosis of leishmania infection of the distal femoral megaprosthesis. The patient was administered amphotericin B for a total of 10 days and gradually became afebrile. Two months after treatment the patient was readmitted with high fever, pancytopenia, liver and spleen enlargement, and chest pain. Radiographs of the chest showed lobar pneumonia and pleural effusion; thoracentesis showed Mycobacterium avium intracellulare lung infection. Despite multi-regimen antibiotic therapy and chemotherapy, disease progressed and the patient died 19 months after osteosarcoma resection and distal femoral megaprosthetic reconstruction from cancer-related complications.

Publications Copernicus
Download
Citation