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<front>
<journal-meta>
<journal-id journal-id-type="publisher">JBJI</journal-id>
<journal-title-group>
<journal-title>Journal of Bone and Joint Infection</journal-title>
<abbrev-journal-title abbrev-type="publisher">JBJI</abbrev-journal-title>
<abbrev-journal-title abbrev-type="nlm-ta">J. Bone Joint Infect.</abbrev-journal-title>
</journal-title-group>
<issn pub-type="epub">2206-3552</issn>
<publisher><publisher-name>Ivyspring</publisher-name>
<publisher-loc>Göttingen, Germany</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.7150/jbji.43801</article-id>
<title-group>
<article-title>&lt;em&gt;Clostridium cadaveris&lt;/em&gt; Osteomyelitis: an Unusual Pathogen which Highlights the Importance of Deep Tissue Sampling in Chronic Osteomyelitis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Corrigan</surname>
<given-names>Ruth Alexandra</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Lomas-Cabeza</surname>
<given-names>Jose</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Stubbs</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>McNally</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
</contrib-group><aff id="aff1">
<label>1</label>
<addr-line>Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Windmill Road, Oxford, OX3 7HE, UK.</addr-line>
</aff>
<aff id="aff2">
<label>2</label>
<addr-line>Nuffield Department of Clinical Laboratory Sciences, Radcliffe Department of Medicine, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK.</addr-line>
</aff>
<pub-date pub-type="epub">
<day>30</day>
<month>03</month>
<year>2020</year>
</pub-date>
<volume>5</volume>
<issue>2</issue>
<fpage>96</fpage>
<lpage>100</lpage>
<permissions>
<copyright-statement>Copyright: &#x000a9; 2020 Ruth Alexandra Corrigan et al.</copyright-statement>
<copyright-year>2020</copyright-year>
<license license-type="open-access">
<license-p>This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this licence, visit <ext-link ext-link-type="uri"  xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link></license-p>
</license>
</permissions>
<self-uri xlink:href="https://jbji.copernicus.org/articles/5/96/2020/jbji-5-96-2020.html">This article is available from https://jbji.copernicus.org/articles/5/96/2020/jbji-5-96-2020.html</self-uri>
<self-uri xlink:href="https://jbji.copernicus.org/articles/5/96/2020/jbji-5-96-2020.pdf">The full text article is available as a PDF file from https://jbji.copernicus.org/articles/5/96/2020/jbji-5-96-2020.pdf</self-uri>
<abstract>
<p>&lt;p class=&quot;p p-first-last&quot; id=&quot;__p2&quot;&gt;&lt;em&gt;Clostridium cadaveris&lt;/em&gt;, named following its identification in human corpses, is an unusual pathogen. We report the first case of &lt;em&gt;C. cadaveris&lt;/em&gt; osteomyelitis. This case highlights the importance of deep tissue sampling and appropriate culture to correctly identify causative pathogens and guide targeted antimicrobial therapy in difficult-to-treat infections like chronic osteomyelitis.&lt;/p&gt;</p>
</abstract>
<counts><page-count count="5"/></counts>
</article-meta>
</front>
<body/>
<back>
<ref-list>
<title>References</title>
<ref id="ref0">
<label>0</label><mixed-citation publication-type="other" xlink:type="simple">Klein E. Ein Beitrag zur Bakteriologie der Leichenverwesung. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1899;1:278–84. [Google Scholar]</mixed-citation>
</ref>
<ref id="ref1">
<label>1</label><mixed-citation publication-type="other" xlink:type="simple">Brook I. Anaerobic bacterial bacteremia: 12-year experience in two military hospitals. J Infect Dis. 1989;160:1071–5.</mixed-citation>
</ref>
<ref id="ref2">
<label>2</label><mixed-citation publication-type="other" xlink:type="simple">de Virgilio C, Klein S, Chang L. et al. Clostridial bacteraemia: implications for the surgeon. Am Surg. 1991;57(6):388–93.</mixed-citation>
</ref>
<ref id="ref3">
<label>3</label><mixed-citation publication-type="other" xlink:type="simple">Herman R, Goldman IS, Bronzo R. et al. Clostridium cadaveris: an unusual cause of spontaneous bacterial peritonitis. Am J Gastroenterol. 1992;87(1):140–2.</mixed-citation>
</ref>
<ref id="ref4">
<label>4</label><mixed-citation publication-type="other" xlink:type="simple">Gucalp R, Motyl M, Carlisle P. et al. Clostridium cadaveris bacteremia in the immunocompromised host. Med Pediatr Oncol. 1993;21(1):70–2.</mixed-citation>
</ref>
<ref id="ref5">
<label>5</label><mixed-citation publication-type="other" xlink:type="simple">Morshed S, Malek F, Silverstein RM. et al. Clostridium cadaveris septic arthritis after total hip arthroplasty in a metastatic breast cancer patient. J Arthroplasty. 2007;22(2):289–282.</mixed-citation>
</ref>
<ref id="ref6">
<label>6</label><mixed-citation publication-type="other" xlink:type="simple">Mormeneo Bayo S, Ferrer Ceron I, Martín Juste P. et al. A review of difficult-to-treat post-traumatic osteomyelitis: Role of Clostridium celerecrescens. Rev Esp Cir Ortop Traumatol. 2020 [Epub ahead of print]</mixed-citation>
</ref>
<ref id="ref7">
<label>7</label><mixed-citation publication-type="other" xlink:type="simple">Tremp M, Oranges CM, Majewski M. et al. Clostridial Infection After Open Fractures of the Lower Extremity - Report of Two Cases and Discussion of Pathomechanism and Treatment. In vivo. 2020;34(1):291–298. [PMC free article]</mixed-citation>
</ref>
<ref id="ref8">
<label>8</label><mixed-citation publication-type="other" xlink:type="simple">Vijayvargiya P, Garrigos ZE, Rodino KG. et al. Clostridium paraputrificum septic arthritis and osteomyelitis of shoulder: A case report and review of literature. Anaerobe. 2019 doi: 10.1016/j.anaerobe.2019.102105.</mixed-citation>
</ref>
<ref id="ref9">
<label>9</label><mixed-citation publication-type="other" xlink:type="simple">Abusnina W, Shehata M, Karem E. et al. Clostridium sporogenes bacteremia in an immunocompetent patient. ID Cases. 2019;15:e00481.. doi:10.1016/j.idcr.2018.e00481. [PMC free article]</mixed-citation>
</ref>
<ref id="ref10">
<label>10</label><mixed-citation publication-type="other" xlink:type="simple">Hirai J, Sakanashi D, Huh JY. et al. The first human clinical case of chronic osteomyelitis caused by Clostridium hydrogeniformans. Anaerobe. 2017;45:138–141.</mixed-citation>
</ref>
<ref id="ref11">
<label>11</label><mixed-citation publication-type="other" xlink:type="simple">Perkins MJ, Snesrud E, McGann P. et al. Clostridium sphenoides Chronic Osteomyelitis Diagnosed Via Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry, Conflicting With 16S rRNA Sequencing but Confirmed by Whole Genome Sequencing. Military Medicine. 2017;182(1-2):e1669–e1672.</mixed-citation>
</ref>
<ref id="ref12">
<label>12</label><mixed-citation publication-type="other" xlink:type="simple">Mutoh Y, Hirai R, Tanimura A. et al. Osteomyelitis due to Clostridium innocuum in a patient with acute lymphoblastic leukemia: case report and literature review. Springerplus. 2015;4:385.. doi:10.1186/s40064-015-1176-3. [PMC free article]</mixed-citation>
</ref>
<ref id="ref13">
<label>13</label><mixed-citation publication-type="other" xlink:type="simple">Virot E, Servien E, Laurent F. et al. Reactivation of Clostridium tertium bone infection 30 years after the Iran-Iraq war. Case Reports. 2015;2015:bcr2014209169. [PMC free article]</mixed-citation>
</ref>
<ref id="ref14">
<label>14</label><mixed-citation publication-type="other" xlink:type="simple">Ibnoulkhatib A, Lacroix J, Moine A. et al. Post-traumatic bone and/or joint limb infectons due to Clostridium spp. OTSR. 2012;98(6):696–705.</mixed-citation>
</ref>
<ref id="ref15">
<label>15</label><mixed-citation publication-type="other" xlink:type="simple">Mischnik A, Zimmermann S, Bekeredjian-Ding I. et al. Relapse of posttraumatic osteomyelitis due to Clostridium celerecrescens. Infection. 2011;39:491–494.</mixed-citation>
</ref>
<ref id="ref16">
<label>16</label><mixed-citation publication-type="other" xlink:type="simple">Taylor SM, Wolfe CR, Dixon TC. et al. Wound botulism complicating internal fixation of a complex radial fracture. J Clin Microbiol. 2010;48(2):650–653. [PMC free article]</mixed-citation>
</ref>
<ref id="ref17">
<label>17</label><mixed-citation publication-type="other" xlink:type="simple">Jiang W, Abrar S, Romagnoli M. et al. Clostridium glycolicum wound infections: case reports and review of the literature. J Clin Microbiol. 2009;47(5):1599–1601. [PMC free article]</mixed-citation>
</ref>
<ref id="ref18">
<label>18</label><mixed-citation publication-type="other" xlink:type="simple">Tekaya R, Saidane O, Abdelmoula L. et al. Spondylodiscite à Clostridium clostridiiforme. Med Mal Infect. 2008;38(6):332–33.</mixed-citation>
</ref>
<ref id="ref19">
<label>19</label><mixed-citation publication-type="other" xlink:type="simple">Kihiczak D, Epstein R. Clostridium septicum osteomyelitis with intramedullary gas on CT and MR imaging. AJR Am J Roentgenol. 1999;172:1457–1458.</mixed-citation>
</ref>
<ref id="ref20">
<label>20</label><mixed-citation publication-type="other" xlink:type="simple">Shetty AK, Heinrich SD, Steele RW. Clostridium septicum osteomyelitis: case report and review. Pediatr Infect Dis J. 1998;17(10):927–9.</mixed-citation>
</ref>
<ref id="ref21">
<label>21</label><mixed-citation publication-type="other" xlink:type="simple">Scanlan DR, Smith MA, Isenberg HD. et al. Clostridium bifermentans bacteremia with metastatic osteomyelitis. J Clin Microbiol. 1994;32(11):2867–2868. [PMC free article]</mixed-citation>
</ref>
<ref id="ref22">
<label>22</label><mixed-citation publication-type="other" xlink:type="simple">Spitzer RD, Ratzan KR. Chronic osteomyelitis due to Clostridium clostridiiforme. South Med J. 1991;84:671–672.</mixed-citation>
</ref>
<ref id="ref23">
<label>23</label><mixed-citation publication-type="other" xlink:type="simple">Brook I, Frazier EH. Anaerobic osteomyelitis and arthritis in a military hospital: A 10-year experience. Am J Med. 1993;1:21–28.</mixed-citation>
</ref>
<ref id="ref24">
<label>24</label><mixed-citation publication-type="other" xlink:type="simple">Neimkin RJ, Jupiter JB. Metastatic nontraumatic Clostridium septicum osteomyelitis. J. Hand Surg. 1985: 1OA; 281-283.  [PubMed]</mixed-citation>
</ref>
<ref id="ref25">
<label>25</label><mixed-citation publication-type="other" xlink:type="simple">Lawson PA, Citron DM, Tyrrell KL. et al. Reclassification of Clostridium difficile as Clostridioides difficile (Hall and O&apos;Toole 1935) Prévot 1938. Anaerobe. 2016;40:95–99.</mixed-citation>
</ref>
<ref id="ref26">
<label>26</label><mixed-citation publication-type="other" xlink:type="simple">Gredlein CM, Silverman ML, Downey MS. Polymicrobial septic arthritis due to Clostridium species: case report and review. Clin Infect Dis. 2000: 30(3); 590-4.  [PubMed]</mixed-citation>
</ref>
<ref id="ref27">
<label>27</label><mixed-citation publication-type="other" xlink:type="simple">Poduval RD, Mohandas R, Unnikrishnan, D. et al. Clostridium cadaveris bacteremia in an immunocompetent host. Clin Infect Dis. 1999;29(5):1354–1355.</mixed-citation>
</ref>
<ref id="ref28">
<label>28</label><mixed-citation publication-type="other" xlink:type="simple">Sheehy SH, Atkins BA, Bejon P. et al. The microbiology of chronic osteomyelitis: Prevalence of resistance to common empirical anti-microbial regimens. J. Infect. 2010;60:338–343.</mixed-citation>
</ref>
<ref id="ref29">
<label>29</label><mixed-citation publication-type="other" xlink:type="simple">McNally M, Nagarajah K. Osteomyelitis. Orthop Trauma. 2010;24(6):416–429. [Google Scholar]</mixed-citation>
</ref>
<ref id="ref30">
<label>30</label><mixed-citation publication-type="other" xlink:type="simple">Sigmund IK, McNally MA. Diagnosis of bone and joint infections. Orthop Trauma. 2019;33(3):144–152. [Google Scholar]</mixed-citation>
</ref>
<ref id="ref31">
<label>31</label><mixed-citation publication-type="other" xlink:type="simple">Govaert GAM, Kuehl MD, Atkins BL. et al. Diagnosing Fracture-Related Infection: Current concepts and recommendations. Orthop Trauma. 2020;34(1):8–17. [PMC free article]</mixed-citation>
</ref>
</ref-list>
</back>
</article>