<p class="p p-first-last" id="__p2"><em>Clostridium cadaveris</em>, named following its identification in human corpses, is an unusual pathogen. We report the first case of <em>C. cadaveris</em> osteomyelitis. This case highlights the importance of deep tissue sampling and appropriate culture to correctly identify causative pathogens and guide targeted antimicrobial therapy in difficult-to-treat infections like chronic osteomyelitis.</p>