JBJI Journal of Bone and Joint Infection JBJI J. Bone Joint Infect. 2206-3552 Ivyspring Göttingen, Germany 10.7150/jbji.29731 Meta-analysis of sonicate fluid in blood culture bottles for diagnosing periprosthetic joint infection Li Cheng 1 Renz Nora 1 Thies Cristina Ojeda 2 Trampuz Andrej 1 Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Center for Musculoskeletal Surgery (CMSC), Berlin, Germany Hospital Universitario 12 de Octubre, Madrid, Spain 24 12 2018 3 5 273 279 Copyright: © 2018 Cheng Li et al. 2018 This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/ This article is available from https://jbji.copernicus.org/articles/3/273/2018/jbji-3-273-2018.html The full text article is available as a PDF file from https://jbji.copernicus.org/articles/3/273/2018/jbji-3-273-2018.pdf

<p class="p p-first" id="__p2"><strong>Introduction:</strong> Periprosthetic joint infection (PJI) is the most serious complication after arthroplasty, and the diagnosis of PJI is still challenging with modern medical technology. To improve the diagnostic rate, combined diagnostic methods are gradually beginning to be used to diagnose PJI. Sonication is one accurate way to diagnose PJI, but there is minimal research regarding the diagnostic value of sonicate fluid (SF) in blood culture bottles (BCB). Therefore, we evaluated this combined diagnostic method by meta-analysis.</p><p id="__p3"><strong>Methods:</strong> We searched English publications in electronic databases regarding the use of sonicate fluid in blood culture bottles (SF-BCB) for diagnosing PJI, screened the literature according to inclusion criteria, assessed the quality of the selected literature, and collected information regarding SF-BCB.</p><p id="__p4"><strong>Results:</strong> This meta-analysis includes 4 studies that evaluated SF-BCB for the diagnosis of PJI. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and diagnostic odds ratio (DOR) are 0.85 (95% Confidence interval [CI], 0.77 to 0.91), 0.86 (CI, 0.81 to 0.91), 5.34 (CI, 3.13 to 9.11), 0.16 (CI, 0.06 to 0.48) and 39.01 (CI, 9.04 to 168.35), respectively. The area under the curve (AUC) of the summary receiver operating characteristic (SROC) is 0.9186 (standard error, 0.0205).</p><p class="p p-last" id="__p5"><strong>Conclusion:</strong> SF-BCB has great value for the microbiological diagnosis of PJ, especially for patients with prior antibiotic treatment.</p>

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